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Clinical Trials

Updated May 2018

Ongoing Clinical Trials at University Orthopaedic Associates, LLC
By Patricia Seuffert, MS, ANP

The ongoing research represents our interests in trauma, knee surgery, sports medicine, osteoporosis, and joint replacement.

Several of our UOA surgeons participated in two international studies (FAITH and HEALTH trials) as investigators and although our participation is complete, results from these trials are now being disseminated.

Two abstracts will be presented this October at the Orthopaedic Trauma Association (OTA) annual meeting in Orlando, Florida.  Abstract #1 will present data analysis on a number of patients who suffered a second fracture after their initial hip fracture.  Abstract #2 will identify associations between hip fractures and complications after the fracture.

Two FAITH secondary papers have recently been published. These papers helped to identify risk factors associated with revision surgery. These factors include female sex, obesity, cigarette smoking to name just a few.   Findings in both of these papers will help clinicians in their decision making when caring for the newly diagnosed hip fracture patient.


  1. Sprague S, Schemitsch EH, Swiontkowski M, Della Rocca GJ, Jeray KJ, Liew S, Slobogean G, Bzovsky S, Heels-Ansdell D, Zhou Q, Bhandari M; FAITH Investigators. Factors Associated with Revision Surgery Following Internal Fixation of Hip Fractures. J Orthop Trauma. 2018 May;32(5):223-230.
  2. Sprague S, Bhandari M, Heetveld MJ, Liew S, Scott T, Bzovsky S, Heels-Ansdell D, Zhou Q, Swiontkowski M, Schemitsch EH; FAITH investigators. Factors Associated with Health-Related Quality of Life, Hip Function, and Health Utility after Operative Management of Femoral Neck Fractures. Bone Joint J. 2018;100-B:361-369.


UOA is also participating in a post-marketing trial for an approved knee implant.  David A. Harwood, MD is the principal investigator in this joint replacement protocol.  We have enrolled a total of 28 total knee replacement patients that are part of a phase IV clinical trial to examine the long term outcome of the Smith & Nephew Legion Knee implant.  We have just completed following our enrolled patients for a total of 7 years.  We have retained all but 3 patients who withdrew their participation early.  The sponsor of the trial will review the collected data for all sites this year.  We are anxiously awaiting the results of this trial.

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